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Regensburg 2019 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 52: Poster: Active Matter, Microswimmer, Microfluidics

DY 52.4: Poster

Donnerstag, 4. April 2019, 15:00–18:00, Poster B2

Antimargination of microparticles and platelets in branching vessels — •Christian Bächer1, Alexander Kihm2, Lukas Schrack1,3, Lars Kaestner4, Matthias W. Laschke5, Christian Wagner2, and Stephan Gekle11Biofluid Simulation and Modeling, Bayreuth, Germany — 2Experimental Physics, Saarland University, Saarbrücken, Germany — 3Institute for Theoretical Physics, Innsbruck, Austria — 4Institute for Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg/Saar, Germany — 5Institute for Clinical & Experimental Surgery, Saarland University, Homburg/Saar, Germany

Microparticles in red blood cell suspension are studied in a vessel confluence and a bifurcation - typical geometries for blood vessel networks. Using three-dimensional Lattice-Boltzmann simulations we find strong effects on cell and particle distribution: flowing through a confluence triggers an additional, surprisingly stable cell-free layer in the center with microparticles undergoing antimargination into this central cell-free layer. In contrast to the perturbed margination in a vessel confluence, we obtain full microparticle margination in branching vessels. Margination in branching vessels and antimargination behind confluences may explain in vivo findings of strongly different platelet distribution in arterioles (mainly bifurcations) and venules (mainly confluences).

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