Regensburg 2019 – wissenschaftliches Programm
SOE 19: Focus Session: Theory of Stochastic Processes with Applications in Biology (joint session SOE/BP/DY/AKjDPG)
SOE 19.7: Topical Talk
Donnerstag, 4. April 2019, 18:00–18:30, H17
Reconstructing the topographic landscape of epithelial-mesenchymal plasticity — •Francesc Font-Clos, Stefano Zapperi, and Caterina A. M. La Porta — Center for Complexity and Biosystems, University of Milan, Italy
We construct a topographic map underlying epithelial-mesenchymal plasticity by combining numerical simulations, statistical physics methods and analysis of bulk and single-cell gene expression data. The map reveals a multitude of metastable hybrid phenotypic states, separating stable epithelial and mesenchymal states, and is reminiscent of the free energy measured in glassy materials and disordered solids.
Topography of epithelial-mesenchymal plasticity, Francesc Font-Clos, Stefano Zapperi, Caterina A. M. La Porta, Proceedings of the National Academy of Sciences Jun 2018, 115 (23) 5902-5907; DOI: 10.1073/pnas.1722609115