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Regensburg 2019 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 1: X-ray Imaging

ST 1.5: Vortrag

Montag, 1. April 2019, 16:00–16:15, H48

Characterization and optimization of a small animal in-vivo grating-based dark-field CT scanner — •Stephan Umkehrer1, Katharina Hellbach2, Ali Önder Yildirim3, Julia Herzen1, and Franz Pfeiffer1, 41Chair of Biomedical Physics and Munich School of BioEngineering, TU Munich, Garching — 2Department of Radiology, University Hospital, LMU Munich, Munich — 3Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Center Munich, Munich — 4Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, TU Munich, Munich

In contrast to conventional X-ray attenuation, grating-based dark-field imaging provides sample small-angle scattering information. Especially for early detection of lung diseases, such as pulmonary emphysema, pulmonary fibrosis, or pulmonary carcinoma the dark-field signal provides promising diagnostic value. Using in vivo radiography, structural pathologic changes in the lung tissue due to alveolar structure change can be observed by a decreased dark-field signal. Even though research has been very successful concerning the increased sensitivity of the dark-field signal compared to conventional absorption contrast the diagnostic potential of dark-field computed tomography (CT) for early pulmonary disease detection and assess has to be investigated. In this presentation, we will describe the recent progress of the first preclinical small animal in-vivo dark-field CT scanner, which was developed in collaboration with Bruker MicroCT (former Skyscan).

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