Regensburg 2019 – wissenschaftliches Programm
ST 5.6: Vortrag
Mittwoch, 3. April 2019, 11:00–11:15, Kunsthalle
Image guided steering of a magnetically coated swimmer with Magnetic Particle Imaging — •Anna C. Bakenecker1, Anselm von Gladiss1, Michael Herbst2, Heinrich Lehr2, Matthias Graeser3,4, Mandy Ahlborg1, Thomas Friedrich1, and Thorsten M. Buzug1 — 1Institute of Medical Engineering, University of Lübeck, Germany — 2Bruker Biospin MRI GmbH, Ettlingen, Germany — 3Section of Biomedical Imaging, University Medical Center Eppendorf, Hamburg, Germany — 4Insititute of Biomedical Imaging, Technical University Hamburg, Germany
Magnetic actuation is of great interest for the local delivery of therapeutics towards regions which are difficult to access. A 3D printed swimmer, which is coated with magnetic nanoparticles was developed. This swimmer of mm-size can be used as an untethered transporter through the vascular system. The steerability as well as the simultaneous visualization of the swimmer is demonstrated by using magnetic particle imaging (MPI). MPI is a very promising imaging technique, because it enables three-dimensional real-time imaging of magnetic nanoparticles without ionizing radiation. It is highly beneficial for the combination with magnetic actuation, since the magnetic fields of MPI scanners cannot only be used for the image acquisition but for magnetic actuation as well. The steerability of the swimmer in a vessel phantom is demonstrated and MPI images of the moving swimmer are shown.