Regensburg 2019 – wissenschaftliches Programm

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SYDN: Symposium Physics of Self-Organization in DNA Nanostructures

SYDN 1: Physics of Self-Organization in DNA Nanostructures

SYDN 1.1: Hauptvortrag

Donnerstag, 4. April 2019, 09:30–10:00, H1

Functional DNA Nanostructures and Their Applications — •Itamar Willner — Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

The base sequence of DNA encodes substantial structural and functional information into the polymer. The triggered reconfiguration of nucleic acids provides means to control the functions of DNA nanostructures and materials. This will be exemplified with four examples: 1. DNA machines triggered by auxiliary stimuli, such as a bipedal walker or interlocked circular DNA nanostructures (catenanes), will be introduced. The application of the machines to organize switchable and programmed Au nanoparticle assemblies will be presented. 2. DNA origami tiles provide versatile building blocks for the guided assembly of functional structures. This will be exemplified with the reconfiguration of origami dimer tiles and the use of the system for programmed catalysis. In addition, the triggered unlocking of holes in origami tile, and the use of the nano-holes as confined environments for programmed catalysis will be introduced. 3. DNA-based constitutional dynamic networks (CDNs) provide organized assemblies mimicking complex biological networks. The adaptive and emergent, signal-triggered, functions of CDNs will be introduced, and their application for the programmed transcription/translation of proteins will be addressed. 4. Reversible, signal-triggered DNA-based hydrogels, revealing switchable stiffness properties, are constructed. The stimuli-responsive hydrogels are applied as shape-memory matrices, self-healing materials, signal-controlled drug carriers and mechanical devices.

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