Rostock 2019 – wissenschaftliches Programm
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MO: Fachverband Molekülphysik
MO 22: Posters 3: Cluster, Strong Field Physics, and Experimental Techniques
MO 22.19: Poster
Donnerstag, 14. März 2019, 16:15–18:15, S Foyer LLM
Towards Single-Molecule Detection on a Smartphone — •Lars Richter1,2, Carolin Vietz2, Max L. Schütte2, Qingshan Wei3, Aydogan Ozcan4, Philip Tinnefeld5, and Guillermo P. Acuna2,6 — 1Departement of Physics, Humboldt University of Berlin, Berlin, Germany — 2Institute for Physical & Theoretical Chemistry, and BRICS, and LENA, Braunschweig University of Technology, Germany — 3Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, USA — 4Electrical & Computer Engineering Department, and Bioengineering Department, and CNSI, and Department of Surgery, University of California, Los Angeles, USA — 5Department of Chemistry and Center for NanoScience, Ludwig Maximilian University of Munich, Germany — 6Department of Physics, University of Fribourg, Switzerland
Microscopy techniques based on smartphones have seen a rapid development during the last years. Necessitating only a small number of additional camera components, enables smartphone microscopes to detect analytes such as cells, viruses and bacteria.
We demonstrate and test a smartphone microscopy system with single-molecule sensitivity. By employing optical nanoantennas which rely on the plasmonic enhancement with metal nanoparticles, the emitted light intensity per molecule is greatly amplified.
The experimental results show that monochrome camera sensors outperform colour sensors reaching a sensitivity of 10 fluorophores. Furthermore, preliminary results indicate the detection of single fluorescent molecules on a smartphone.