Rostock 2019 – wissenschaftliches Programm

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MS: Fachverband Massenspektrometrie

MS 3: Mass Spectrometry - Posters

MS 3.15: Poster

Dienstag, 12. März 2019, 16:30–18:15, S Fobau Physik

Construction of a new electrospray ionization time of flight mass spectrometer (ESI-TOF-MS) for femtosecond laser experiments — •Peter Krüger and Karl-Michael Weitzel — Philipps-Universität Marburg, Germany

Femtosecond laser mass spectrometry (fs-LMS) is a versatile method with many different applications [1]. It not only offers great temporal and mass resolution, but also allows non-resonant excitation schemes due to high laser peak intensities.

However, the technique relies on the sample of interest being in the gas phase, which poses a challenge regarding high molecular masses. This limitation can be overcome by employing an electrospray ionization (ESI) source, which allows intact vaporization and soft ionization of heavy molecules, e.g. biopolymers or pharmaceuticals [2].

In the current work we present a new apparatus specifically designed to combine the advantages of ESI and fs-LMS. The experimental setup consists of an ESI source, an ion guide, and an interaction region where the ion beam and a fs-laser beam overlap. This interaction region constitutes the source of an ion time-of-flight mass spectrometer (ion TOF-MS) and an electron TOF-MS with spatially resolved detector. The setup is described and first experiments aimed at the photoionization/-dissociation of cations and photodetachment/-dissociation of anions by the femtosecond laser pulses will be discussed.

[1] K.W.D. Ledingham, R.P. Singhal, Int. J. Mass Spectrom. Ion Proc., 163, 149, (1997) [2] J.B. Fenn, Angew. Chemie, 42, 3871, (2003)