Dresden 2020 – wissenschaftliches Programm
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BP 10.21: Poster
Montag, 16. März 2020, 17:30–19:30, P2/3OG
Why do rigid tumors contain soft cancer cells? — •Thomas Fuhs1, Franziska Wetzel1, Anatol W. Fritsch1, Dapeng Bi2, Roland Stange1, Steve Pawlizak1, Tobias R. Kiesling1, Erik Morawetz1, Steffen Grosser1, Frank Sauer1, Jürgen Lippoldt1, Fred Renner1, Sabrina Friebe1, Mareike Zink1, Bahriye Aktas3, Lars-Christian Horn3, Klaus Bendrat4, Axel Niendorf4, Michael Höckel3, and Josef A. Käs1 — 1Leipzig University, Germany — 2Northeastern University, Boston, USA — 3University Hospital Leipzig, Germany — 4Pathology Hamburg-West, Germany
Palpatation used since acient times, utilizes that solid tumors are stiffer than surrounding tissue. However, cancer cell lines are softer, which facilitates invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment? Or are soft cells already present inside a rigid primary tumor? We investigate primary samples from patients with mammary and cervical carcinomas on multiple length scales from tissue level down to single cells. We show that primary tumors a highly heterogeneous in their mechanical properties on the tissue level as well as cells do exhibit a broad distribution of rigidities, with a higher fraction of softer and more elongated cells compared to normal tissue. Mechanical modelling based on patient data reveals that tumors remain solid containing a significant fraction of very soft cells. Moreover, it predicts that in such tissues, softer cells spontaneously self-organize into multicellular streams, which we observe experimentally.