Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Poster III

BP 10.3: Poster

Montag, 16. März 2020, 17:30–19:30, P2/3OG

Effect of channel geometry on RBC shape in microfluidic devices — •Mohammed Nouaman1, Alexander Kihm1, Steffen Recktenwald1, Lars Kaestner1,2, and Christian Wagner11Saarland University, Experimental Physics, Dynamic of Fluids, Campus E2 6, Saarbrücken, Germany. — 2Saarland University, Theoretical Medicine & Biosciences, Campus University Hospital, Homburg, Germany

Red blood cells (RBCs) exhibit a broad range of different shapes in capillary flows depending on various parameters, such as flow velocity, applied pressure drop, and lateral position. In microfluidic flows in small rectangular channels (e.g. 10x12 microns), two main stable RBC shapes exist. For low-pressure drops, RBCs preferentially show a croissant-like shape, a transition toward slipper-like RBCs can be observed with the increase of pressure drop. However, the effect of the channel dimensions on this transition remains vaguely unknown. Therefore, we perform detailed statistical analysis of the RBC shapes, covering a range of microfluidic channel height and width (e.g. 10-30 microns). In order to enable an unbiased analysis of RBC shape, we further use a convolutional neuronal network CNN, which provides fast data processing and determination of the transition point between the two main stable RBC shapes.

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