Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Poster VI

BP 18.25: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/2OG

Active gel model of onset of the movement in one-dimensional cell motility — •Yuan-Heng Tseng1 and Hsuan-Yi Chen1,21Department of Physics, National Central University, Zhongli, Taiwan — 2Institute of Physics, Academia Sinica, Nankang, Taiwan

To understand how the intracellular mechanical mechanism affects the motion of a cell, we develop a one-dimensional model for cell migration on a solid substrate. This model includes contractile force from actomyosin network, viscous stress in the cytoskeleton, actin polymerization at the ends of the cell, drag force due to substrate and drag force due to cell-substrate bonds. Our numerical solutions show that in addition to the contractility, polymerization-cell-movement feedback, and spontaneous symmetry breaking in the distribution of cell-substrate bonds helps to initiate cell crawling. This is illustrated by phase diagrams for static and motile states.

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