Dresden 2020 – scientific programme
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BP: Fachverband Biologische Physik
BP 31: Computational Biophysics (joint session BP/CPP)
BP 31.10: Talk
Thursday, March 19, 2020, 12:30–12:45, SCH A251
Quantifying membrane curvature sensing — •Kai Steffen Stroh1 and Herre Jelger Risselada1,2 — 1Institute for Theoretical Physics, Göttingen, Germany — 2Leiden Institute of Chemistry, Leiden, The Netherlands
When considering the interplay of lipid membranes and proteins, membrane curvature is an important factor, as it can act as a control mechanism for protein function. Several proteins feature subunits that serve as membrane curvature sensors. This sensing ability together with the spatial information provided by membrane curvature allows for site specific binding, and thus regulation of, e.g., transport processes.
Naturally, the curvature-dependent binding free energy provides valuable quantitative information about a protein’s curvature sensing abilities. Therefore, we present a novel molecular dynamics simulations protocol to obtain such free energy profiles.