Dresden 2020 – wissenschaftliches Programm
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MM: Fachverband Metall- und Materialphysik
MM 24: Materials for Sensors and Actuators
MM 24.2: Vortrag
Dienstag, 17. März 2020, 12:00–12:15, IFW B
Implantable Highly Compliant Devices for Heating of Internal Organs: Toward Cancer Treatment — •Tetiana Voitsekhivska1, Gilbert Santiago Canón Bermúdez1, Tetyana Yevsa2, Inga Hochnadel2, Jürgen Fassbender1, and Denys Makarov1 — 1Helmholtz-Zentrum Dresden Rossendorf e.V., Institute of Ion Beam Physics and Materials Research, Bautzner Landstrasse 400, 01328 Dresden, Germany — 2Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Flexible electronics can revolutionize the health care sector. Despite numerous functional flexible devices already demonstrated, tumor treatment remains unexplored in this field. We realized a highly compliant device for targeted heat treatment of tumor sites of internal organs [1], consisting of a 6 μm-thick polymeric foil hosting a heater and temperature sensor, coated with a 5 μm-thick encapsulation layer. We study the electro-thermal and mechanical characterization of the devices and demonstrate that they can be efficiently used to thermally impact normal and cancerous tissues of autochthonous murine models with liver cancer. The device withstood more than 50 bending cycles at 2.5 mm bending radius, retaining the accuracy of 0.2 °C. The developed highly compliant device paves the way for handling of exophytic tumor nodules via thermal destruction of tissue, targeted drug release, or enhancement of antitumor immune responses.
[1] G.S. Canón Bermúdez et al., Adv. Eng. Mater. 21, 1900407 (2019).