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MO: Fachverband Molekülphysik
MO 8: MO Poster 2
MO 8.10: Poster
Dienstag, 10. März 2020, 17:00–19:00, Empore Lichthof
Unraveling the ultrafast dynamics in indole-water — •Jolijn Onvlee1,2, Joss Wiese1,3, Jovana Petrovic1, Terry Mullins1, Sebastian Trippel1,2, and Jochen Küpper1,2,3,4 — 1Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Hamburg — 2Center for Ultrafast Imaging, Universität Hamburg — 3Department of Chemistry, Universität Hamburg — 4Department of Physics, Universität Hamburg
For a protein in water, hydrogen bonds between the protein and surrounding water molecules strongly affect its folding and thereby also its function. When hydrogen bonds between a protein and surrounding water molecules break, for instance via absorption of UV radiation, the protein structure changes and inactivation of the protein can occur.
We investigated the ultrafast dynamics of the hydrogen-bond breaking between proteins and water in a bottom-up approach by studying the indole molecule – the chromophore of tryptophan, which is the most strongly near-UV absorbing common amino acid – and the indole-water complex, which serves as a model system for the interaction between proteins and water. We produce pure samples of indole and the indole-water complex in the gas phase using a molecular beam and the electrostatic deflector, with which we spatially separate molecular species. The ultrafast dynamics following UV absorption of these molecular species were studied in a pump-probe ion-imaging approach. We also performed laser-induced electron diffraction experiments, with which we aim to record a molecular movie of the hydrogen-bond breaking in indole-water with high spatiotemporal resolution.