Hannover 2020 – wissenschaftliches Programm

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MS: Fachverband Massenspektrometrie

MS 3: New Developments and Techniques

MS 3.1: Vortrag

Montag, 9. März 2020, 15:15–15:30, f128

Generation and detection of mass-selected neutral polypeptide beamsJonas Schätti2, Moritz Kriegleder1, Maxime Debiossac1, Michael Kerschbaum1, •Marcel Strauss1, Philipp Geyer1, Marcel Mayor2,3, Valentin Köhler2, and Markus Arndt11Faculty of Physics, University Vienna — 2Department of Chemistry, University Basel — 3Institute of Nanotechnology, Karlsruhe Institute of Technology

Studies of biomolecules in the gas phase have attracted increasing interest because they allow elucidating the relative influence of the solvent shell or the determination of molecular polarizabilities, which are challenging to measure on ionic species. Here we report on novel concepts for the generation and detection of neutral polypeptide beams. For the preparation of neutral biomolecular beams we have designed and synthesized photocleavable subunits that can be generically labelled to peptides and proteins and allow us to gain control over the molecular charge state in high vacuum, using intense laser light. We demonstrate site-specific photo-activated cleavage neutralization in the gas phase, with high spatial control and precise timing for polypeptides even up to insulin [1]. While neutral biomolecules may be detected by a second photocleavage stage for post-ionization, we discuss new realizations of superconducting nanowire devices (SNWD) as detectors for slow ions and even neutral particles.
[1] Schätti et al., Chem. Commun. 55, 12507(2019)

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