BPCPPDYSOE21 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 22: Poster Session III - Charged Soft Matter and Theory and Simulation
CPP 22.14: Poster
Mittwoch, 24. März 2021, 16:30–18:30, CPPp
In-situ GISAXS Investigation of Sprayed Drugs on a Cellulose Based Matrix — •Elisabeth Erbes1,2, Naireeta Biswas1,2, Stephan V. Roth1,3, Simone Techert1,2, Matthias Schwartzkopf1, Calvin Brett1,6, Jose Velazquez Garcia1, Sreevidya Thekku Veedu1, Korneliya Goordeyeva3, Andrei Chumakov1, and Peter Müller-Buschbaum4,5 — 1DESY, 22607 Hamburg, Germany — 2Institute for X-ray Physics, Goettingen University, 37077 Goettingen, Germany — 3Department of Fibre and Polymer Technology, KTH, 100 44 Stockholm, Sweden — 4Department of Physics, Technical University Munich, 85748 Garching, Germany — 5MLZ, Technical University Munich, 85748 Garching, Germany — 6Department of Mechanics, KTH, 100 44 Stockholm, Sweden
These experiments show the first steps to a novel drug carrier strategy for a controlled dosage of anti-COVID-19 drugs. The drugs were embedded into a matrix made of a mixture of hydrophilic carboxymethylated nanocellulose (CMC) hydrogel and disordered hydrophobic peptide hydrogel (P). This gives the opportunity to vary the local uptake in hydrophobic or hydrophilic compartments in the matrix. The structural intercalation and the time-resolved process were investigated with in-situ grazing incidence small angle X-ray scattering (GISAXS) experiments. By using the spraying technique the drug concentration can be tuned for a personalized treatment of the patients. This poster focuses only on the structural change analysis of the CMC fibers. For the analysis of the peptide part please see the poster of Naireeta Biswas.