BPCPPDYSOE21 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 12: Posters DY - Fluid Physics, Active Matter, Complex Fluids, Soft Matter and Glasses (joint session DY/BP)
DY 12.11: Poster
Montag, 22. März 2021, 14:00–16:30, DYp
Cell fitness in growth driven active matter: decoupling turnover rate and homeostatic pressure predictors — •Yoav G. Pollack1, Philip Bittihn1, and Ramin Golestanian1,2 — 1Max Planck Institute for Dynamics and Self-Organization (MPIDS), Goettingen, 37077, Germany — 2Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford, OX1 3PU, UK
In growth-driven dense cellular active matter, cell dynamics and competition are governed by the intricate relations between growth, proliferation, removal (e.g. death, extrusion) and mechanical interactions. Though the rates at which a cell proliferates or dies have already been established as a significant factor for fitness, homeostatic pressure was recently suggested as an equivalent predictor of fitness and one that can be more easily measured. Here we show that this equivalence in not universal and can be broken. By introducing an additional time-scale that governs the duration of the single-cell removal process in a simple growing dumbbell model of cells, the homeostatic pressure is partially decoupled from the turnover rate, leading to a distinct prediction for each. When the two factors are modulated in this way in a simulated competition assay of a mixture of two cell species in a closed 1D channel, we show that while the homeostatic pressure does not predict well which species triumphs, the turnover rate does. A good fitness measure is important in studies of tumor growth, bacterial evolution, etc. and this result is a first step in understanding for which scenarios is the homeostatic pressure a valid predictor.