BPCPPDYSOE21 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 27: Fluid Physics 3 - organized by Stephan Weiss and Michael Wilczek (Göttingen)
DY 27.6: Vortrag
Dienstag, 23. März 2021, 15:50–16:10, DYa
Impact of the gut motility on nutrient absorption and bacterial growth — •Agnese Codutti1,2 and Karen Alim1,2 — 1MPIDS, Goettingen, Germany — 2TUM Physics, Munich, Germany
The small intestine malfunctioning and its microbiome have been linked to serious diseases (from obesity, diabetes, Crohn disease to depression and anxiety). Therefore, the study of the physics underlaying such malfunctioning and the healthy gut behavior is of vital importance. In our work, we aim to theoretically model the tight link between gut motility, fluid flows, nutrients absorption and bacterial growth. We extend the Taylor dispersion approach to the case of an absorbing tube with moving walls, and we use a system of coupled equations to model nutrients and bacteria. We show that the gut motility deeply impacts the nutrient absorption: motility patterns with slow flows such as segmentation increase the nutrient absorption due to the long permanence times, while motility patterns with strong flows such as peristalsis reduce the absorption. On the contrary, segmentation favours the bacterial growth, while peristalsis reduces it. Therefore, we prove that the gut alternates such patterns to maximize nutrient absorption and minimise bacterial growth.