SKM 2021 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 13: Focus session: Nonlinear Dynamics of the Heart II (organized by Markus Bär, Stefan Luther and Ulrich Parlitz)
DY 13.2: Vortrag
Donnerstag, 30. September 2021, 14:00–14:15, H2
Optogenetics control of spiral waves dynamics in cardiac tissue — •Sayedeh Hussaini1, Aidai Mamyraiym kyzy1, Laura N. Diaz-Maue1, Johannes Schroeder-Schetelig1, Vishallini Venkatesan1, Raul A. Quiñonez Uribe1, Claudia Richter1, Vadim Biktashev2, Rupamanjari Majumder1, Valentin Krinski1, and Stefan Luther1 — 1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\"ottingen, Germany — 2Exeter University, Exeter, England, United Kingdom
The heart is an excitable medium. The formation of spiral waves in the heart is the main cause of life-threatening cardiac arrhythmias. Defibrillation is a method to control these abnormal waves. Due to the significant side effects of this method, the development of alternative methods is needed. To do this, we need to deepen our knowledge of the dynamics of spiral waves. For this, Optogenetics has shown its great potential. In this work, using optogenetics we control the dynamics of a spiral wave in a two-dimensional domain of the mouse heart. We apply global and structured illumination patterns at different light intensities. In the sub-threshold regime illumination, we observed the tendency of the spiral wave to drift along the LI gradient. This observation provides us with a new mechanistic insight into optogenetic defibrillation. Global epicardial illumination of the cardiac surface leads to an intramural exponential decay of illumination which may cause the drift of a spiral wave towards the epicardium, where the wave may be terminated with supra-threshold illumination.