SKM 2021 – wissenschaftliches Programm

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MA: Fachverband Magnetismus

MA 18: Posters Magnetism V

MA 18.33: Poster

Freitag, 1. Oktober 2021, 10:00–13:00, P

Hyperthermia setup for efficient nanoparticle heating — •Daniel Kuckla, Amirarsalan Asharion, Julia-Sarita Brand, Vinzenz Jüttner, and Cornelia Monzel — Heinrich-Heine-Universität Düsseldorf

All biological systems are temperature dependent. Of special interest is the influence of elevated temperatures on malignant tissue and how this can be exploited for medical treatments. One approach called "magnetic hyperthermia" uses bio-functionalized magnetic nanoparticles (MNPs) which heat in an alternating magnetic field. By targeting MNPs to the malignant cells, a spatially selective heating of tissue is realized. Here, we present a hyperthermia setup, which allows to image the behaviour of cells marked with MNPs on a microscope while being subjected to an alternating magnetic field. We provide a comprehensive characterization of the setup components and magnetic fields generated, as well as strategies to limit off-target power dissipation. We further quantify the heat generated by MNPs in well-defined in vitro and biomimetic environments. The efficient generation of high-frequency magnetic fields and direct observation of MNP responses will provide valuable information on the heat generation mechanism in different environments.