SAMOP 2023 – wissenschaftliches Programm

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MS: Fachverband Massenspektrometrie

MS 3: Mass Spectrometry Applications

MS 3.3: Vortrag

Mittwoch, 8. März 2023, 15:15–15:30, F128

Mass spectrometric determination of the speciation of radium in the human digestive tract using ESI-MS — •Linus Holtmann, Ahmadabdurahman Shamoun, Beate Riebe, and Clemens Walther — Institut für Radioökologie und Strahlenschutz, Leibniz Universität Hannover, Hannover, Germany

Radionuclides pose a potential radio- and chemotoxic hazard to humans when ingested. Knowledge of radionuclide interaction in the digestive tract at the molecular and cellular level is necessary for risk assessment and to contribute to an element-specific decontamination strategy.

Synthetic biofluids prepared according to the UBM protocol (BARGE) are used to investigate the speciation of radium in the human digestive tract. The biofluids are analyzed in the presence and absence of Ra(II)/Ba(II) by mass spectrometry using electrospray ionization (ESI-MS). In our experiments, an Orbitrap mass spectrometer allows the measurement of the speciation without any chemical separation. The identification of barium-containing species takes place via specific isotope pattern signatures. Algorithms specifically tailored to the evaluation of complex mass spectra are used.

In addition, the influence of different decorporation and complexing agents on the speciation of Ra(II)/Ba(II) in the simulated digestive process is studied. This way, element-specific decorporation strategies are investigated for their potential efficacy after oral ingestion of radium.