SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Poster Session I
BP 11.33: Poster
Dienstag, 28. März 2023, 12:30–15:30, P1
Impact of biomolecular condensates on endocytosis — •Tyler Harmon1, Max Ferrin2, and Frank Jülicher3 — 1Leibniz Institute for Polymer Research, Dresden, Germany — 2University of California, Berkeley, USA — 3Max Planck Institute for the Physics of Complex Systems
Endocytosis is a mechanism that cells use to import material from outside the cell without allowing it immediate access to the cytoplasm. This process involves a section of a cell membrane that is folded inward and then separated into a membrane coated sphere containing the cargo called a vesicle. The process involves recruiting many different protein components to the membrane. We model this recruitment as the formation of a small droplet (biomolecular condensate) located on the membrane. We show using a theoretical model that the presence of a droplet has two major impacts. It creates an additional barrier to initializing endocytosis and it accelerates the process once started. Importantly, the magnitude of this barrier is reduced as droplets get larger. Taken together, droplets are ideal for improving the robustness of endocytosis. It provides a natural checkpoint where cells can ensure they are ready to proceed with endocytosis and, once started, helps ensure that it doesn't stop halfway.