SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Poster Session I

BP 11.7: Poster

Dienstag, 28. März 2023, 12:30–15:30, P1

Long-Term Stability, Biocompatibility and Magnetization of Suspensions of Isolated Bacterial Magnetosomes — F. Mickoleit¹, C. Jörke², •R. Richter³, S. Rosenfeldt⁴, S. Markert¹, I. Rehberg³, A. S. Schenk⁵, O. Bäumchen³, D. Schüler¹, and J. H. Clement² — ¹Dept. Microbiology, University of Bayreuth, D-95447 Bayreuth, Germany — ²Dept. Hematology and Medical Oncology, Jena University Hospital, D-07747 Jena, Germany — ³Experimental Physics V, University of Bayreuth, D-95447 Bayreuth, Germany — ⁴Physical Chemistry I, University of Bayreuth, D-95447 Bayreuth, Germany — ⁵Physical Chemistry - Collidal Systems, University of Bayreuth, D-95447 Bayreuth, Germany

Magnetosomes are magnetic nanoparticles biosynthesized by magnetotactic bacteria. Due to a genetically strictly controlled biomineralization process, the ensuing magnetosomes have been envisioned as agents for biomedical and clinical applications. In the present work, we examine the stability parameters of magnetosomes isolated from Magnetospirillum gryphiswaldense upon storage as a suspension in a buffer solution at 4^∘C and N₂ atmosphere for one year in the absence of antibiotics. The magnetic potency, measured by the saturation magnetization of the particle suspension [1], drops by 2/3 within this year - about ten times slower than at ambient air and room temperature. The particle size distribution, the integrity of the surrounding magnetosome membrane, the colloidal stability, and the biocompatibility turn out to be not severely affected by long-term storage. — [1] Mickoleit F., et al. (2018). ACS Appl. Mater. Interfaces 10(44), 37898.