SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Poster Session I

BP 11.78: Poster

Dienstag, 28. März 2023, 12:30–15:30, P1

Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement by Monte-Carlo based particle scattering Simulations — •Marc Benjamin Hahn¹ and Julian Mateo Zutta Villate² — ¹Bundesanstalt für Materialforschung und -prüfung, 12205 Berlin, Germany — ²Pontificia Universidad Javeriana, Bogota, Colombia

Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of radiation damage in biomolecules and tissue. To apply them effectively during cancer therapy their influence on the locally delivered dose has to be determined.[1] Hereby, the AuNP locations strongly influence the energy deposit in the nucleus, mitochondria, membrane and the cytosol of the targeted cells. In this work, two newly developed continuous and discrete-geometric models for simulations of AuNP in cells are presented.[2] We apply the presented models in Monte-Carlo particle scattering simulations to characterize the energy deposit in cell organelles by radioactive 198AuNP. They emit beta and gamma rays and are therefore considered for applications with solid tumors. Differences in local dose enhancement between randomly distributed and nucleus targeted nanoparticles are compared. Hereby nucleus targeted nanoparticels showed a strong local dose enhancement in the radio sensitive nucleus.[1] J.M. Zutta Villate and M.B. Hahn, Eur. Phys. J. D. 73 (2019) 95. [2] M.B. Hahn and J.M. Zutta Villate, Sci Rep 11 (2021) 6721.