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BP: Fachverband Biologische Physik
BP 12: Biopolymers and Biomaterials (joint session BP/CPP)
BP 12.1: Talk
Wednesday, March 29, 2023, 09:30–09:45, TOE 317
Interaction of laminin and brain cells with ion implanted titania nanotube scaffolds — •Jan Frenzel1,2,3, Astrid Kupferer1,2, and Stefan Mayr1,2 — 1Leibniz Institute of Surface Engineering (IOM), 04318 Leipzig, Germany — 2Division of Surface Physics, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germanyany — 3Research Group Biotechnology and Biomedicine, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germany
Brain-machine interfaces enable symptomatic treatment of neurodegenerative diseases by modulating neural activities and enjoy great popularity when brain tissue is assessed ex vivo. However, current-use interface materials are troubled by numerous challenges concerning loss of long-term adhesion, rejection reactions, and glial scarring. We show that ion-implanted titania nanotube scaffolds (TNS) are a promising candidate for dealing with these issues because they combine high biocompatibility with adequate electrical conductivity. Based on our experiments, we explain how changes in the adsorption of laminin and the viability/adhesion of neurons and glial cells caused by ion implantation can be described by alterations in surface characterisics. The high neuron viability observed on all TNS, but suppressed glial cell formation on implanted TNS, demonstrates the potential as a future interface material. We acknowledge funding by SMWK (100331694). Reference: Frenzel et al., Nanomaterials 2022, 12, 3858. https://doi.org/10.3390/nano12213858