SKM 2023 – scientific programme

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BP: Fachverband Biologische Physik

BP 13: Signaling, Biological Networks

BP 13.2: Talk

Wednesday, March 29, 2023, 10:00–10:15, BAR 0106

Protein Dynamics in the Complex Physical Environment of the Synapse — •Simon Dannenberg, Sarah Mohammadinejad, and Stefan Klumpp — Institut für Dynamik komplexer Systeme Georg-August-Universität Göttingen, Göttingen, Germany

The synapse is a complex environment that is densely packed with proteins and has an internal geometry structured by membranes. This affects the mobility of proteins involved in signal transmission and hence, their availability at corresponding reaction sides.

In our work we use dynamic Monte Carlo simulations to investigate the influence of different physical features of the synapse on protein mobility. The simulations are parameterized by mobility measurements via FRAP experiments. Our approach revealed an unexpectedly high sensitivity of the experiments on the geometry of the synapses as well as dependence of protein fluxes on synaptic features such as axon diameter and synapse size.