SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 28: Poster Session II

BP 28.34: Poster

Donnerstag, 30. März 2023, 18:00–20:00, P2/EG

Cell migration on micropatterns - how regular is the motion of different cell types? — •Annika A. Vogler, Sebastian W. Krauss, Radhakrishnan A. Veettil, Florian Rehfeldt, and Matthias Weiss — Experimental Physics I, University of Bayreuth, Germany

During processes like embryonic development, wound healing, or cancer metastasis, cells are often migrating in complex and obstacle-rich environments. Microstructured surfaces offer a versatile opportunity to model such environments and study cell migration under controlled conditions. Recent studies on cells that migrate in fairly simple two-state micropatterns have revealed, for example, a rich and nonlinear migration dynamics [1]. Following up on this study, we have explored the migration dynamics of non-cancerous MCF-12A cells on simple dumbbell patterns in comparison to malignant MDA-MB-231 cells. As a result, we observed that MCF-12A cells exhibit a strikingly more regular migration pattern while trajectories of cancerous cells appeared more stochastic. In particular, the path of non-tumorigenic cells was mainly focused on the edges of the pattern whereas malignant cells explored the whole available adhesion area. These results suggest differences in how the external environment is perceived by the internal biochemical state of cells.

[1] Brueckner, Fink, Schreiber et al., Nat. Phys. 15, 595 (2019)