SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 5: Focus Session NanoAgents
BP 5.8: Vortrag
Montag, 27. März 2023, 17:15–17:30, TOE 317
Precise micro-manipulations via multiplexed feedback-controlled thermoviscous flows — •Elena Erben1, Nicola Maghelli1, Weida Liao2, Antonio Minopoli1, Eric Lauga2, and Moritz Kreysing1 — 1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany — 2DAMTP, University of Cambridge, UK
Methods for precise micro-manipulation are highly relevant for many problems in biological research such as cell patterning and controlled droplet fusion. Thermoviscous flows [1] hold great potential for manipulations in biological systems since they can be induced optically and enable non-invasive in-vivo perturbations [2]. Recently, we developed a novel optofluidic manipulation method based on feedback-controlled thermoviscous flows. This technique facilitates the automatic positioning of a single micro-particle, with a precision of up to 24 nm [3]. Our approach can be multiplexed to the parallel manipulation of multiple particles, thus facilitating dynamic micropatterning. Furthermore, we found that positioning of multiple particles can be greatly accelerated by leveraging highly complex flow patterns that result from multiplexing. We anticipate that combining our approach with elaborate theoretical modelling will increase the precision and speed of this manipulation method even more, facilitating translation onto applications in the life sciences and beyond.
[1] Weinert et al. Phys. Rev. Lett. 2008; [2] Mittasch et al. Nat. Cell Biol. 2018; [3] Erben et al. Opt. Express 2021.