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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 30: Biopolymers and Biomaterials I (joint session BP/CPP)

CPP 30.5: Talk

Wednesday, March 29, 2023, 10:45–11:00, TOE 317

The migration and search behavior of immune cells — Reza Shaebani and •Franziska Lautenschläger — Saarland University, Saarbrücken

Immune cells have a variety of tasks in the body. For example, dendritic cells act as the *sentinels* searching for pathogens. For this search, the cells need to scan a certain area in an effective way. Here, we investigate how cells optimize the search of such area. We have shown before that all cell types show a correlation of migration speed and persistence [1]. We later found that cells which strongly correlate these two parameters are particularly good at searching objects [2]. Interestingly, we found that cells do not keep the memory of their speed as long as the memory of their persistence [3]. Now, we investigate how we can disturb this migration and search behavior, preferable by altering the cytoskeleton [4].

1.*Maiuri, P., et al., Actin flows mediate a universal coupling between cell speed and cell persistence. Cell, 2015. 161(2): p. 374-86. 2.*Shaebani, M.R., et al., Persistence-Speed Coupling Enhances the Search Efficiency of Migrating Immune Cells. Phys Rev Lett, 2020. 125(26): p. 268102. 3.*Shaebani, M.R., M. Piel, and F. Lautenschläger, Distinct Speed and Direction Memories of Migrating Cells Diversify Their Possible Search Strategies. arXiv. 4.*Shaebani, M.R., et al., Vimentin provides target search efficiency and mechanical resilience for dendritic cell migration. bioRxiv, 2020: p. 2020.12.18.423401.