SKM 2023 – wissenschaftliches Programm
DY 33.6: Vortrag
Mittwoch, 29. März 2023, 16:15–16:30, ZEU 250
Gift of gab: Probing the limits of dynamic concentration-sensing across a network of communicating cells — •Mohammadreza Bahadorian1,2, Christoph Zechner1,2,3, and Carl D. Modes1,2,3 — 1Max Planck Institut for Molecular Cell Biology and Genetics (MPI-CBG), 01307 Dresden, Germany — 2Center for Systems Biology Dresden (CSBD), 01307 Dresden, Germany — 3Cluster of Excellence Physics of Life, TU Dresden, 01069 Dresden, Germany
Many systems in biology and other sciences employ collaborative, collective communication strategies for improved efficiency and adaptive benefit. One such paradigm of particular interest is the community estimation of a dynamic signal, when, for example, an epithelial tissue of cells must decide whether to react to a given dynamic external concentration of stress-signaling molecules. At the level of dynamic cellular communication, however, it remains unknown what effect, if any, arises from communication beyond the mean field level. What are the limits and benefits to communication across a network of neighbor interactions? What is the role of Poissonian versus super-Poissonian dynamics in such a setting? How does the particular topology of connections impact the collective estimation and that of the individual participating cells? In this article we construct a robust and general framework of signal estimation over continuous-time Markov chains in order to address and answer these questions.