SKM 2023 – wissenschaftliches Programm
DY 42.7: Poster
Donnerstag, 30. März 2023, 13:00–16:00, P1
Adaptive microvascular remodeling under flow — Fatemeh Mirzapour-Shafiyi, •Leonie Karr, and Karen Alim — School of Natural Sciences, Technische Universität München
Vessel morphology is adapted to minimise energetic costs of dissipation and homogenize flow transport in the network. Resource-deprived tissues produce chemotactic agents to induce vessel formation during development and in tissue homeostasis. The primitive, mesh-like vascular network formed initially through neovascularisation is highly ramified. Later, vascular network is normalised into a hemodynamically preferred tree-like structure. The normalisation process, termed vessel remodeling, leads to an organ-specific network architecture which better meets the metabolic needs of its surrounding tissue. As vessel growth and remodeling is found impaired in various disease states, several factors regulating vessel formation and branching morphology were identified over the past decades. However, while some of these factors have been undergoing clinical trials, their effects on transport properties of the altered vessel morphology are not fully elucidated yet. Establishing a perfusable human vasculature-on-a-chip (hVoC) model system, here we aim to investigate how vascular morphology correlates with flow field. Our hVoC model allows extensive quantitative analyses of network morphology and adaptive remodeling under fluid flow applied by a low-pressure syringe pump. Results of our analyses will contribute to the next generation therapeutics targeting vessel development.