SKM 2023 – wissenschaftliches Programm

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MA: Fachverband Magnetismus

MA 23: Poster Magnetism I

MA 23.26: Poster

Dienstag, 28. März 2023, 17:00–19:00, P1

Magnetization of magnetotactic bacteria: influence of additional nitrate during incubation — •Nicole Sander, Imke Wellesen, and Mathias Getzlaff — Institute of Applied Physics, Heinrich-Heine-Universität Düsseldorf

Magnetotactic bacteria (MTB) have the ability to orient and migrate along a magnetic field. The orientation of those bacteria is based on intracellular magnetic structures called magnetosomes, which are formed from magnetite surrounded by a lipid-biolayer. These magnetic properties of MTB are currently of interest for magnetic hyperthermia as an application for cancer therapy.

Here we report on new findings how additional nitrate during incubation of MTB can prolong cell formation and increase magnetization. With additional nitrate we found, that the storage in an incubator can be extended and magnetosome concentration per bacteria was increased due to higher cell mass. A feeding of MTB after five days of incubation maximized the messured optical density being a measure for the number of bacteria respectivly a feeding on the seventh day of incubation maximized magnetization. The data was obtained twenty-four hours after adding nitrate and further incubation. Considering a longer incubation period the data shows, that incubating up to fourty-eight hours after feeding bacteria with nitrate apopotsis can be delayed. These findings display an advantage for magnetic hyperthermia because of higher cell mass and magnetosome concentration per cell the specific absorption rate (SAR) will be enlarged. Otherwise for same SAR a smaller concentration of bacteria is needed.