SMuK 2023 – scientific programme
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AKBP: Arbeitskreis Beschleunigerphysik
AKBP 5: Hadron Accelerators
AKBP 5.2: Talk
Tuesday, March 21, 2023, 16:45–17:00, CHE/0184
Tumor irradiation in mice with a laser-accelerated proton beam — •Florian Kroll1, Florian-Emanuel Brack1, Elke Beyreuther1,2, Thomas Cowan1,3, Leonhard Karsch1,2, Josefine Metzkes-Ng1, Jörg Pawelke1,2, Marvin Reimold1,3, Ulrich Schramm1,3, Tim Ziegler1,3, and Karl Zeil1 — 1Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany — 2OncoRay - National Center for Radiation Research in Oncology, Dresden, Germany — 3Technische Universität Dresden, Dresden, Germany
Oncological studies identified beneficial properties of radiation applied at dose rates considerably exceeding the clinical standard of 1 Gy/min. At the Draco PW laser of Helmholtz-Zentrum Dresden-Rossendorf, a laser-driven proton research platform enables research on ultra-high dose rate effects for diverse user-specific small animal models.
Tunable single-shot doses are applied to mm-scale volumes on ns time scales, resulting in instantaneous dose rates around 109 Gy/s. Dose distributions that uniformly cover the sample volume were generated from individual broad-band proton bunches provided by our laser-driven source with unprecedented stability and long-term reliability. Maximum proton energies regularly exceeded 60 MeV.
We conducted the first radiobiological in vivo study with laser-driven protons using human tumors in a mouse model. We show the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay.