SMuK 2023 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 3: Poster Session
ST 3.3: Poster
Mittwoch, 22. März 2023, 11:00–12:30, ZEU/0146
Cell irradiation experiments using a compact ultrafast electron source — •Bastian Löhrl1, Leon Brückner1, Julian Freier1, Luitpold Distel2, and Peter Hommelhoff1 — 1Department Physik, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91058 Erlangen — 2Department Strahlenbiologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen
Dielectric laser acceleration (DLA) could provide new opportunities for radiotherapy [1]. The goal is to build a chip-based (electron) accelerator using nanophotonic structures driven by femtosecond laser pulses. Built into an endoscopic system, such a novel mini-accelerator could be used for highly localized cancer treatment, for example.
Motivated by this goal, we present the successful implementation of a cell irradiation experiment using pulsed electrons. The setup provides a custom-made, compact electron source with adjustable beam energies up to 30 keV. An integrated electrostatic lens enables focusing of the emitted electron beam. The source can provide several thousand electrons per laser pulse. Irradiation-induced DNA double-strand breaks are detected and visualized in different types of cells through γH2AX immunofluorescence staining. We report on the current status of the experiment and the results of the first measurements.
[1] England, R. Joel, et al. "Dielectric laser accelerators." Reviews of Modern Physics 86.4 (2014): 1337.