Dresden 2026 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Franco-German Session: Bacterial Biophysics I
BP 11.6: Vortrag
Dienstag, 10. März 2026, 10:45–11:00, BAR/0106
How substrate stiffness and roughness tune early biofilm development: designing platforms for in situ observation of bacterial behavior — •Mathieu Letrou1, Sofia Gomes1, Kennedy Chagua Encarnacion2, Rebecca Matthias1, Yeraldinne Carrasco Salas1, Elena Murillo Vilella1, Lionel Bureau1, Karin John1, Delphine Débarre1, and Sigolène Lecuyer2 — 1Université Grenoble Alpes, CNRS, LIPhy, Grenoble, France — 2Laboratoire de Physique, ENS de Lyon, CNRS, Lyon, France
Biofilm formation begins with bacterial colonization of substrates, a process that occurs across diverse living tissues and abiotic surfaces. Early bacterial exploration of solid-liquid interfaces, governed by adhesion and individual motility, is a known determinant of the subsequent development and persistence of bacterial colonies. Yet, how bacteria integrate environmental cues at these interfaces and adapt their behavior accordingly remains poorly understood. In this talk, I will present recent experimental approaches to generate microenvironments with precisely controlled properties, that also enable the in situ imaging of bacterial behavior within microfluidic channels. Using the pathogen Pseudomonas aeruginosa, I will show how substrate stiffness, rigidity gradients, and the presence of dispersed obstacles can alter surface exploration, thus modifying the onset of colony formation [1]. These results highlight how physical properties of solid-liquid interfaces can regulate early biofilm development and suggest new avenues for controlling surface colonization.
[1] Letrou et al., Eur Phys J E Soft Matter, 48(10-12):70 (2025)
Keywords: adhesion; microcolony formation; surface motility; pseudomonas aeruginosa; biofilm