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Dresden 2026 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 14: Poster Session II

BP 14.23: Poster

Dienstag, 10. März 2026, 18:00–21:00, P2

A synthetic flow system for modelling the vascular margination effect using microbeads — •Teresa M. Maunz, Alexandra Bienau, Friedrich Simmel, and Karen Alim — School of Natural Sciences, Technical University of Munich, Germany

The margination effect in the blood vasculature causes particles to migrate toward the blood vessel walls due to interactions with red blood cells (RBCs). Margination plays an important role in particle-based drug delivery targeted at the vascular endothelium, which requires contact with the endothelium for delivery. While margination has been studied with simulations and (some) experiments, how to control margination for synthetic particles is underexplored and requires thorough experimental testing of multiple variable parameters. Here, we present a synthetic microfluidic system dedicated to investigating the margination effect. The base system consists of a microfluidic channel carrying a binary suspension of beads, mimicking RBCs and marginating particles. Physiological conditions are emulated by tuning parameters that have been predicted to be crucial for the emergence and prominence of the margination effect, such as vessel diameter, RBC volume fraction, RBC deformability, the size ratio between RBCs and particles, and flow characteristics. We anticipate that our system will contribute to identifying key parameters that enable the margination effect, thereby improving our understanding of blood flow and facilitating the development of future drug delivery testing models.

Keywords: Margination effect; Vasculature; Synthetic Biology

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