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BP: Fachverband Biologische Physik

BP 14: Poster Session II

BP 14.24: Poster

Dienstag, 10. März 2026, 18:00–21:00, P2

Effects of perfluorocarbons on lipid monolayers and protein adsorption — •Jaqueline Savelkouls¹, Michael Paulus¹, Christian Thiering¹, Michelle Dargasz², Lena Friedrich¹, Mike George¹, Prashant Hitaishi³, Svenja Hövelmann^3,4, Oleg Konovalov⁵, Eric Schneider¹, Gordon Scholz¹, Chen Shen⁴, and Metin Tolan¹ — ¹Technische Universität Dortmund, Germany — ²Universität Siegen, Germany — ³Christian-Albrechts-Universität zu Kiel, Germany — ⁴DESY, Hamburg, Germany — ⁵ESRF, Grenoble, France

Lipid monolayers serve as biomimetic models to study structural and functional aspects of protein-membrane interactions, which are essential for understanding physiological functions. Investigating how perfluorocarbon (PFC) effects on these interactions may aid new therapeutic strategies. This study examines the influence of various PFCs on structural changes of lung-surfactant-like DPPA and DPPC monolayers at different initial surface pressures, as well as on the adsorption behavior of surface-active proteins. Experiments were conducted at beamlines ID10 (ESRF, Grenoble) and P08 (PETRA III, Hamburg) under ambient conditions using a combined grazing incidence X-ray diffraction and X-ray reflectivity study. The results demonstrate that the effect of the PFCs on the lipid structure and protein adsorption depends on the chemical characteristics of the PFCs, the lipid type, and the lipid phase. This work will discuss how the adsorption of PFCs at the membrane promotes protein association.

Keywords: Perfluorocarbon gases; Langmuir films; Proteinadsorption; Grazing incidence X-ray diffraction; X-ray reflectivity