Dresden 2026 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.41: Poster
Dienstag, 10. März 2026, 18:00–21:00, P2
Quantification of in vivo flow of blood cells - adhesion cascade — •Khadija Larhrissi1, Felix Maurer1, Selina Wrublewsky2, Alexis Darras3, and Christian Wagner1 — 1Department of Experimental Physics, University Campus, Saarland University, 66123 Saarbrucken, Germany. — 2Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany — 3School of Physics, University of Bristol, Bristol, United Kingdom)
Red blood cells (RBCs) constitute the majority of cells in the blood and play a key role in transporting oxygen to tissues and organs. On the other hand, leukocytes, also known as white blood cells (WBCs), make up approximately 1% of the total blood volume in most mammals. The flow of these cells ensures the body's defense against various viral and bacterial infections. The WBCs exhibit two modes of motion: a fast flow mode where they move with the surrounding fluid, and a slower rolling mode where they partly adhere to the wall, whereas RBCs simply flow with the surrounding fluid. In this study, our objective is to examine the influence of geometry and distribution on the flow of WBCs. To achieve this, we used Golden Syrian Hamsters as a model system to quantify the flow of cells by fluorescence microscopy and compare their behavior in different networks of vessels. Additionally, since some WBCs are larger in size than the capillaries they pass through, we will examine the impact of this size difference on their flow.
Keywords: white blood cells; margination; red blood cells; fluorescence microscopy; hamster