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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.72: Poster
Dienstag, 10. März 2026, 18:00–21:00, P2
Structure and Dynamics of Network-Forming Protein Solutions using SAXS and megahertz XPCS — •Adrian Maximilian Roda Lentz1, Michael Paulus1, Michelle Dargasz2, Florian Wieland3, and Christian Gutt2 — 1Department Physics/DELTA, TU Dortmund, Dortmund, Germany — 2Department of Physics, University of Siegen, Siegen, Germany — 3Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany
This study explores the structure of networks formed by the biopolymer hyaluronic acid, together with the dynamics of embedded proteins, in this framework ferritin and apoferritin. Hyaluronic acid is a major constituent of synovial fluid and a key component in tissue dynamics and repair; therefore, characterization is essential for advancing biomedical applications. Static Small-Angle X-ray Scattering (SAXS) conducted at P10 (DESY) and BL2 (DELTA) was employed for structural characterization, complemented by megahertz Xray Photon Correlation Spectroscopy (XPCS) at MID (EuXFEL) to quantify the dynamics. First results indicate a pronounced impact of hyaluronic acid on the collective diffusion behavior of proteins.
Keywords: SAXS; XPCS; Hyaluronic Acid; Structure; Dynamics