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BP: Fachverband Biologische Physik

BP 14: Poster Session II

BP 14.74: Poster

Dienstag, 10. März 2026, 18:00–21:00, P2

Investigating molecular mechanisms of signaling in the multistep phosphorelay system of Magnaporthe oryzae via All-Atom Molecular Dynamics Simulations — •Jonas Paulus¹, Dennis Martin¹, Antonia Preuß¹, Milena Runge², Stefan Jacob², and Lukas Stelzl¹ — ¹Institut für molekulare Physiologie, Mainz, Germany — ²Institut für Biotechnologie und Wirkstoff-Forschung, Mainz, Germany

Pathogenic fungi cause an annual loss of 15% of the world's major crops and the phenylpyrrole class of fungicides are upon the most successful to combat these pathogens, precisely because of their specificity and outstanding resistance management. The mode of action (MoA) takes place in a multistep phosphorelay system (MSP) thereby hyperactivating the high osmolarity glycerol (HOG) signaling pathway, but has not yet been clarified in detail on molecular level. Using all-atom molecular dynamics (MD) simulations, we investigate the structural and functional mechanisms of the cytosolic osmosensor MoHik1, its phosphotransfer signaling cascade, and nuclear import of downstream effectors. With this, we aim to design a multidimensional model of signal encryption and fungicide action in fungal MSP systems which will provide both, fundamental insights into fungal signal transduction and the chance to shed light on MSP systems as target for antifungal strategies.

Keywords: Magnaporthe oryzae; Osmosensing; All-Atom Molecular Dynamics Simulations; phosphotransfer signaling cascade