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BP: Fachverband Biologische Physik
BP 14: Poster Session II
BP 14.89: Poster
Dienstag, 10. März 2026, 18:00–21:00, P2
Protein self-assembly, infinitely complex yet simple? — •Lukas Kalvoda1 and Martin Lenz1,2 — 1LPTMS, CNRS, Université Paris-Saclay — 2PMMH, CNRS, ESPCI Paris, PSL University
Cells rely on protein self-assembly to form functional complexes, but a lack of regulation gives rise to pathological fibers in diseases like Alzheimer’s and sickle cell anemia. Why proteins robustly form these well-defined morphologies is largely unknown.
Beyond the molecular details, the complexity of proteins in shape and interactions suggests that their self-assembly may be governed by the laws of statistical physics. We introduce an analytical lattice model of anisotropic self-assembling particles to study what we term the “infinite complexity limit”. Therein the number of distinct interactions grows to infinity. Strikingly, in this limit, the “molecular” details of the interactions do not matter anymore. Instead their distribution and extreme value statistics determine the self-assembly outcome.
Keywords: self-assembly; complexity; cavity method; frustration