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BP: Fachverband Biologische Physik
BP 20: Protein Structure and Dynamics
BP 20.9: Vortrag
Mittwoch, 11. März 2026, 17:30–17:45, BAR/0106
Probing membrane protein dynamics on lipid-functionalized graphene transistors through low-frequency noise — •Florian Steinbach1, Mykola Fomin1, Eduard Haar2, Svetlana Vitusevich3, Mykhaylo Petrychuk3, Christian Ungermann2, and Carola Meyer1 — 1Institute of Physics, University of Osnabrück — 2Department of Biology/Chemistry and Center for Cellular Nanoanalytics, University of Osnabrück — 3Institute of Biological Information Processing (IBI-3), Forschungszentrum Jülich
Graphene field-effect transistors (GFETs) functionalized with lipid monolayers provide a controlled and label-free platform for studying membrane-associated proteins [1]. Here, we present electronic transport experiments where the Rab7-like GTPase Ypt7 is immobilized within a lipid monolayer. While there is not electrostatic gating effect observed, the addition of the protein causes a pronounced increase in low-frequency 1/f noise. This noise signal is diminished upon binding of the membrane tethering HOPS complex [2]. The persistence of distinct noise signatures despite strong screening indicates a transduction mechanism that may circumvent the screening within the Debye length.
[1] M. Fomin, L. Jorde, F. Steinbach, C. You, C. Meyer, Phys. Status Solidi B 2300324 (2023).
[2] M. Fomin et al, accepted for publication in Fluctuation and Noise Letters (2025).
Keywords: GFET; Flicker Noise; Membrane proteins; Rab; Protein dynamics