Dresden 2026 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 3: Tissue Mechanics I
BP 3.2: Vortrag
Montag, 9. März 2026, 10:00–10:15, BAR/0205
Mechano-chemical stabilisation of topological defects in an elasto-nematic sheet — •Suganthan Senthilkumar1, Kinneret Keren2, and Marko Popović1,3 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Technion-Israel Institute of Technology, Haifa, Israel — 3Ruder Bošković Institute, Zagreb, Croatia
Self-organisation of patterns during animal development involves a complex interplay of various biophysical and biochemical mechanisms. A striking example is Hydra, where ordered arrays of nematic actin fibers give rise to orientational order on animal-scale with +1 topological defects at the head and foot of an adult animal. To study the nematic patterns observed during Hydra regeneration we recently proposed a mechano-chemical feedback loop that involves orientational order, tissue strain and morphogen gradients[1]. Here we develop a continuum formulation of the same feedback loop in 2d and show that it can stabilise aster shaped +1 topological defects in a self organised manner. We obtain a phase diagram for +1 defect stability using analytical calculations and compare it with vertex model simulations that employ the feedback loop. Finally, we calculate the correction to the mobility coefficient of the +1 defect due to the morphogen field associated with it.
References:
1. Maroudas-Sacks et al Development, (February 2025) 152; doi: https://doi.org/10.1242/dev.204514
Keywords: Mechano-chemical feedback; Orientational order; Topological defects