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BP: Fachverband Biologische Physik

BP 37: Tissue Mechanics II

BP 37.2: Vortrag

Freitag, 13. März 2026, 09:45–10:00, BAR/0106

demonstrating normal tissue sparing with pitz PITZ electron beams in zebrafish embryos — •E Tarakci^1,2,3, C Schulze², C Richard¹, M Gross¹, N Aftab¹, A Aksoy¹, Z Amirkhanyan¹, A Chiravuri^1,2, J Good¹, F Hausmann³, S Khammee¹, Y Komar^1,2,3, M Krasilnikov¹, B Li¹, X Li¹, Z Lotfi¹, G Montoya-Soto¹, F Mueller¹, A Oppelt¹, F Riemer¹, K Suzart¹, I Tinhofer³, D Villani¹, S Worm¹, D Xu¹, S Zeeshan¹, M Frohme², F Stephan¹, S Aminzadeh Gohari¹, and A Grebinyk¹ — ¹Deutsches Elektronen-Synchrotron, DESY, Zeuthen — ²Technische Hochschule Wildau,Wildau — ³Charité Universitätsmedizin Berlin, Berlin

Zebrafish (Danio rerio) embryos provide a sensitive model for studying normal tissue responses. This study was conducted within FLASHlab@PITZ, where PITZ delivers electron beams from conventional to ultra-high dose rates up to 10^15 Gy/s. Wild-type AB embryos at 24 hours post fertilization (hpf) received 10 Gy via conventional X-rays (0.04 Gy/s), low dose rate electrons (LDR, 0.05 Gy/s), or ultra-high dose rate electrons (UHDR, 10^5 Gy/s). At 119 hpf, toxicity was assessed through spinal curvature, pericardial edema, eye diameter, and body length. X-rays and LDR increased toxicity (X-rays: 50% medium, 50% none*mild; LDR: 33% severe, 17% mild, 50% normal). UHDR greatly reduced effects, with no medium or severe toxicity and 42% none and 58% mild changes. These results demonstrate a marked tissue-sparing trend under UHDR conditions and provide early evidence for a FLASH-mediated normal tissue sparing effect.

Keywords: Electron Irradiation; FLASH Effect; Zebrafısh Embryos; Tissue-Sparing