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BP: Fachverband Biologische Physik
BP 37: Tissue Mechanics II
BP 37.5: Vortrag
Freitag, 13. März 2026, 10:30–10:45, BAR/0106
Collective actuation in solid tissues: Dynamics and mechanics of an oscillating tissue shell during morphogenesis — •Zoë Lange1, Henrik Jaeschke1, Lea Möller1, Mariia Golden2, Artemiy Golden2, Marc Pereyra1, Frederic Strobl2, Ernst H.K. Stelzer2, and Franziska Matthäus1 — 1Frankfurt Institute for Advanced Studies — 2Buchmann Institute for Molecular Life Sciences
Morphogenesis relies on coordinated mechanical deformations of embryonic tissues, yet the dynamic material properties that enable these shape changes remain incompletely understood. In the Tribolium castaneum embryo, the extraembryonic serosa tissue forms a closed and oscillating epithelial shell, providing a powerful model to study active mechanical processes in vivo. Here, we combine quantitative live imaging with particle image velocimetry, cell-boundary segmentation, cell-boundary tracking, and stress inference methods to characterize the spatiotemporal mechanics of the oscillatory contractions in the tissue shell. We show that the extraembryonic epithelium behaves as an active elastic solid whose global oscillation emerges from synchronizing cellular contraction. By integrating measured deformation with inferred force maps, we identify a cellular program of mechanosensitive remodeling. Our results provide a mechanistic link between active force production at the cellular scale and emergent morphogenetic dynamics at the tissue scale, establishing the Tribolium tissue shell as a model system for collective actuation in active elastic materials in vivo.
Keywords: active solid; collective actuation; tissue mechanics; force estimation; morphogenesis