Dresden 2026 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.1: Poster
Montag, 9. März 2026, 15:00–17:00, P5
Eco-Friendly PEGylated Iron Oxide Nanoparticles for In Vitro Targeted Delivery and Controlled Release of Docetaxel in SK-OV-3 Ovarian Cancer Cells — •Romesa Soomro1, Che Azurahanim Che Abdullah1,2, and Halima Alem Marchand3 — 11Biophysics Lab, Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43300, Selangor, Malaysia — 22Cancer Research Lab, Institute of Bioscience, Universiti Putra Malaysia, 43300, Selangor, Malaysia — 33Department of Matériaux, Métallurgie, Nanosciences, Université de Lorraine, Nancy, France
Iron oxide nanoparticles were green-synthesized using oolong tea extract as a natural reducing and stabilizing agent. A Taguchi L9 design was applied to optimize reaction parameters and obtain stable nanoparticles with reduced hydrodynamic size. The optimized particles were PEG-coated to improve biocompatibility and subsequently loaded with docetaxel for targeted cancer therapy. Characterization using spectroscopy, diffraction, magnetic measurements, and electron microscopy confirmed successful synthesis and coating, with superparamagnetic behavior and particle sizes below twenty nanometers. Drug release studies showed sustained, pH-responsive release under acidic conditions. Cytotoxicity evaluation using SK-OV-3 ovarian cancer cells demonstrated high biocompatibility of PEG-coated nanoparticles and strong anticancer activity of the docetaxel-loaded system. The results indicate that green-synthesized PEGylated iron oxide nanoparticles provide a promising and sustainable platform for controlled anticancer drug delivery.
Keywords: Iron oxide nanoparticles; Green synthesis; PEGylation; Drug delivery; Cancer nanomedicine