Dresden 2026 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.2: Poster
Monday, March 9, 2026, 15:00–17:00, P5
The Potential Impact of a Novel Chitosan-Titanium dioxide Nanoparticles against Hepatocellular Carcinoma in Rat Model — Omnia Ahmed Mohamed Elbakary1, Eman Ibrahim Kandil1, Sawsan Mohamed Elsonbaty2, Shaimaa El-saied Mohamed1, and •Nermeen Mohamed Elbakary3 — 1Faculty of Science, Biochemistry department, Ain Shams University, Cairo, Egypt — 2Radiation microbiology department, National center for radiation research and technology, Egyptian Atomic Energy Authority, Cairo, Egypt — 3Radiation biology department, National center for radiation research and technology, Egyptian Atomic Energy Authority, Cairo, Egypt
Hepatocellular carcinoma (HCC) the most common type of liver cancer, is the fifth most common malignant tumor type worldwide and the second leading cause of cancer-related death. This study investigates the potential therapeutic effects of novel chitosan-titanium dioxide nanoparticles (Cs-Ti NPs) against hepatocellular carcinoma (HCC) in a rat model. The experimental design included five groups: a healthy control group, a group administered with diethylnitrosamine (DEN) to induce liver carcinogenesis, a group treated with Cs-Ti NPs, a DEN group subsequently treated with 5-Fluorouracil (5-FU), and a DEN group treated with Cs-Ti NPs. DEN was administered orally at 20 mg/kg body weight five times weekly for six weeks to induce tumor formation. Therapeutic interventions with Cs-Ti NPs and 5-FU were applied post-induction. The study evaluated apoptotic markers (Bcl-2, Bax, p53, Caspase-3, Cytochrome C), signaling pathways (MAPK, ULK1, mTOR), and serum tumor markers (AFP, NF-κB, COX-2) via ELISA. Results are expected to elucidate the molecular mechanisms involved and assess the efficacy of Cs-Ti NPs in mitigating HCC progression, potentially offering a new nanotherapeutic avenue for liver cancer treatment.
Keywords: Thiophenes; colorectal cancer; iNOS -; Oncogene -; PPARγ - P53