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BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.30: Poster
Montag, 9. März 2026, 15:00–17:00, P5
Intracellular mechanics in migrating cells — •Jannis Fischer1, Mohammad Amin Eskandari1, Sarah Louisa Lädke1, Till Moritz Münker1, Matthias Krüger2, and Timo Betz1 — 1Third Institute of Physics, Göttingen, Germany — 2Institute for Theoretical Physics, Göttingen, Germany
To fulfill their incredibly large number of different tasks, biological cells have developed mechanisms to adapt their physical properties and appearance, for example cell shape variation or cell migration. It is still not clear whether the changes in these mechanical properties are due to passive or active processes. Investigating and understanding these processes is the core of this work. For this, I will analyze the behavior of migrating cells, which are induced to move alternately on adhesive patterns. To connect the observed dynamics with the underlying mechanical properties and activities, I will use the new quantity of mean back relaxation (MBR). This can not only overcome the low throughput of optical tweezers, but also determine activity and mechanical properties through purely passive observations. With the MBR, we want to answer the question of how cellular shape influences mechanical properties.
Keywords: Intracellular mechanics; Cell migration; Activity; Cytoskeleton; Mean Back Relaxation