Dresden 2026 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 7: Poster Session I
BP 7.44: Poster
Montag, 9. März 2026, 15:00–17:00, P5
What we learned from 6000 patient blood samples measured with deformability cytometry: age, biomarkers, and disease mechanotypes — •Markéta Kubánková1,2, Lena Summa1,2, Maximilian Schlögel1,2, Martin Kräter1,2, Evelyn Maurer1,2, Johanna Fritsche1,2, Paul Müller1,2, Sara Kaliman1,2, Shada Abuhattum1,2, Benedikt Hartmann1,2, Felix Dirla1,2, Manfred Rauh3, Markus Metzler3, and Jochen Guck1,2 — 1Max Planck Institute for the Science of Light, Erlangen, Germany — 2Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany — 3Department of Pediatric and Adolescent Medicine,University Hospital Erlangen, Germany
Deformability cytometry is a label-free microfluidic imaging technique that quantifies mechanical and morphological properties of single cells at ~1000 cells/s directly from brightfield images. Here we analyse >6000 whole-blood measurements from a clinical cohort ranging from newborns to adults. We established age-dependent baselines of size and deformation for the major cell classes. We correlated the features with routine biomarkers such as CRP, IL-6 and PCT. Specific mechanotypes, particularly of neutrophils and monocytes, showed associations with these markers and provided information beyond simple cell counts.We identified disease-related patterns in cell mechanotypes, providing a biophysical basis for future diagnostic applications.
Keywords: cytometry; cells; microfluidics; mechanics; biophysics