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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 41: Biopolymers, Biomaterials and Bioinspired Functional Materials II (joint session CPP/BP)
CPP 41.2: Vortrag
Mittwoch, 11. März 2026, 17:15–17:30, ZEU/0255
Characterizing interactions between glycoproteins and RNA at the lipid membrane interface — •Horacio V. Guzman1 and Viviana Monje2 — 1Biophysics & Intelligent Matter Lab, Material Science Institute of Barcelona, CSIC, Spain — 2Department of Chemical and Biological Engineering, State University of New York at Buffalo, 308 Furnas Hall, Buffalo, USA
Biological membrane interfaces interacting with proteins, nucleic acids, and glycans are integral to many cellular processes. The interplay between membrane lipids and biopolymers is highly sensitive to their flexibility grade, secondary structure, and electrostatics. Consequently, the cell membrane interface experiences changes in local lipid distribution and fluctuation in local properties. Projecting biophysical and structural membrane and biopolymer properties onto a two-dimensional plane simplifies the quantification of molecular signatures by reducing the dimensional space and identifying relevant entropic and short-range interactions at the interface of interest, as well as, characterizing interaction patterns and spatial correlations of complex lipid bilayers as they interact with biopolymers. We compare lipid-lipid interaction patterns in membrane-only systems to the corresponding systems containing small proteins and RNA fragments, respectively. These analyses quantify the effect of peripheral biopolymers on local lipid composition, structure, packing, deformation ratio of the biopolymer, and surface topology of the membrane upon adsorption. Such characterization is crucial for starting with the next-generation rational design of lipid vesicles and lipid-coated RNA drug delivery systems.
Keywords: biopolymers adsorption; Lipid membrane biophysics; Molecular mechanism of adsorption; Computational biophysics; Lipid–biopolymers interactions