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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 46: Poster II

CPP 46.16: Poster

Donnerstag, 12. März 2026, 09:30–11:30, P5

Functional ZnPc-Polymer-Magnetic Nanocomposite Systems for Photodynamic Therapy — •Lungu Ion — Laboratory of Organic/Inorganic Materials for Optoelectronics, Institute of Applied Physics Moldova State University, 60 Al. Mateevici St., MD-2009, Chisinau, Republic of Moldova

Hybrid photosensitizing materials combining organic and magnetic components provide a promising route toward multifunctional systems for photodynamic therapy (PDT). In this work, we investigate the photophysical and magnetically induced processes in a series of functional zinc phthalocyanine (ZnPc) derivatives-ZnPc(COOH)4 and ZnPc(COOH)8 and their conjugates with dextran (Dx) and Fe3O4 nanoparticles. The systems were studied in DMSO/H2O (1:1) solutions using steady-state and time-resolved fluorescence and phosphorescence spectroscopy. All ZnPc-based compounds exhibit characteristic Q-band absorption (650-700 nm) and room-temperature phosphorescence with microsecond lifetimes, confirming efficient intersystem crossing (ISC). Dextran conjugation enhances fluorescence efficiency (ΦF = 2.37 %) and reduces aggregation, whereas Fe3O4 incorporation modifies the spin-orbit coupling, promoting magnetically assisted ISC and additional non-radiative channels. The triplet lifetimes vary between 1-9 μs, depending on molecular substitution and interfacial coupling. These results demonstrate that combining photoactive ZnPc cores with natural polymer matrices and magnetic nanoparticles enables control over excited-state dynamics and ROS generation for biomedical applications.

Keywords: Zinc phthalocyanine derivatives; Photophysical processes; Hybrid nanocomposites